Mouse with 3D-printed ovaries gives birth to healthy pups

18 May, 2017, 01:07 | Author: Joy Garcia
  • 3D-printed ovaries restore fertility in mice

With such ovary implants using 3D printed ovaries, infertile mice restores their fertility and gives birth to healthy pups.

After 3-D printing a biodegradable scaffold, researchers placed the mouse's follicle cells, which are egg-producing cells naturally found in ovaries, into the scaffold, Popular Science noted.

In its one-of-a-kind discovery, experts at the Northwestern University in America were able to successfully implant 3-dimensional ovaries in female mice.

This structure created and infused inside the female mouse allowed the ovarian follicles, which produce hormones during pregnancy, to function properly within the manufactured ovary and led to the creature eventually delivering healthy pups.

This is the first time a functional soft tissue transplant has been 3D-printed, as well as the first time functional 3D-printed organs have been transplanted.

"Our hope is that one day this ovarian bioprosthesis is really the ovary of the future", Northwestern researcher and coauthor Teresa Woodruff told The Guardian.

"Right now, we're able to do that with young mice and the goal ultimately is to provide this to [human] patients".

The shape of the printed ovarian scaffold was modelled closely on the external supporting structure of a real mouse ovary.

HTC U11 With Snapdragon 835 Chipset Unveiled
With its latest flagship device, HTC is taking this a step further by allowing the phone to be operated with a squeeze. The carrier is throwing in two Amazon Echo Dots with U11 preorders for a limited time.

Clapper: US govt 'under assault' by Trump after Comey firing
Some Republicans and Democrats alike raised alarm bells over Comey's firing, over its timing and the potential reasons behind it. The first candidate to arrive for interviews was Alice Fisher, a high-ranking Justice Department official in the George W.

Mnuchin: US partners more comfortable with Trump on trade
Even with the apparent thaw in relations, the USA still stands apart from the rest of G-7 on trade, climate change and other issues.

The researchers undertook the study because they want to find a way to help patients of all ages who undergo treatments (such as for cancer) that impair their ovary function.

A mouse that was born from the bioprosthetic ovary lays next to its mother mouse. The team found a gelatin temperature that allowed it to support itself, leading to the ability to create multiple layers.

Hydrogels are a mixture of 99 percent water and a little bit of polymer, which means they can tend to be quite soft, but the Northwestern team was able to manipulate their gelatin ink to give it a flexible but firm quality. The team showed that blood vessels from each mouse infiltrated the scaffolds. Using a 3D-printer and gelatin, they then printed the basic structure of the ovary, and dosed it with the cultured ovarian follicles.

"What happens with some of our cancer patients is that their ovaries don't function at a high enough level and they need to use hormone replacement therapies in order to trigger puberty", explained Monica Laronda, Assistant Professor at the Ann and Robert H. Lurie Children's Hospital in Illinois, US. The researchers punched out 2-millimeter circles through the scaffolds and implanted 40-50 follicles into each one, creating a "bioprosthetic" ovary. This material is safe for use in humans and is rigid enough for use in surgery, as well as porous enough to allow cells to interact with surrounding tissue.

"The revolution of being able to 3-D print internal organs is going to be move very quickly", Woodruff said.

Woodruff noted she hopes to address some of the challenges soon, such as finding a printing method that ensures the best chances of the egg cells maturing, as well as discovering a material that will create sustainable organs in humans. Alexandra Rutz, co-lead author of the study that appeared Tuesday in the journal Nature Communications, likens 3D-printing the ovaries to working with Lincoln Logs, a classic construction toy based on stacking tiny logs.

The framework underpins the survival of the mouse's juvenile egg cells and the cells that deliver hormones to lift generation.

Recommended:

  • Daredevils climb top of Golden Gate Bridge and perform somersaults

    Daredevils climb top of Golden Gate Bridge and perform somersaults

    Locati said the bridge's security system was "not created to protect thrill-seekers from harming themselves". Unsurprisingly, San Francisco officials aren't taking news of the stunt lightly.

    Activists say Kurdish-led forces advance on IS-held Raqqa

    Erdogan welcomed Trump's election victory last November and said he hoped it would lead to "beneficial steps" in the Middle East. The US-backed forces put pressure on ISIS from each flank, cleared the final neighborhoods of the city, and isolated Tabqah Dam.

    Rafael Nadal lifts title to match Novak Djokovic's record — Madrid Open

    The first game of the second set suggested not: two dire misses and it was break point, and a netted forehand finished it off. Thiem was attempting to become the first ATP Masters 1000, ATP Finals or Grand Slam champion born after 1988.
  • New Instagram face filters are a lot like Snapchat

    New Instagram face filters are a lot like Snapchat

    The new Instagram tool superimposes adornments such as animal ears, hats, makeup and masks over a person's face on the app. This update is the latest in a long line of incremental changes that have been made to the app in the past year.

    Motorola Moto C and Moto C Plus with Android 7.0 Nougat launched

    Motorola team members are doing hard work to release the Moto E4, E4 Plus along with affordable Moto C and C Plus handsets. Unlike the other low-priced smartphones, we don't see any major customizations or the inclusion of bloatware apps.

    North Korea fires ballistic missile: South Korea military

    South Korean President Moon Jae-in has strongly condemned rival North Korea's missile test-launch as a "clear" violation of U.N. The launch has already been criticized by a number of countries, including the United States.
  • Inside the White House: Comey Damage Control And No Easy Way Out

    Inside the White House: Comey Damage Control And No Easy Way Out

    Trump says Comey had told him three times he was not under investigation in the Russian Federation probe. Trump says in the Oval Office that the administration is working to quickly find a successor to Comey.
    Miley Cyrus And Liam Hemsworth Take Their Lovefest To The Big Apple

    Miley Cyrus And Liam Hemsworth Take Their Lovefest To The Big Apple

    But it's not as though the "Wrecking Ball " singer feels like she's missing out. Paris Jackson is "stuck on listening to the classics".
    Jimmy Kimmel to host 90th Academy Awards in 2018

    Jimmy Kimmel to host 90th Academy Awards in 2018

    Jimmy Kimmel will be back as host of the Oscars when the 90th edition of the annual Academy Awards ceremony is held in March. As a result, Kimmel's first Oscars host outing ranked as one of the most memorable in history.
  • We simmed Dele Alli's entire playing career on FM 17

    We simmed Dele Alli's entire playing career on FM 17

    Juventus probably have the best defensive unit in Europe but, other than that, I don't see anything better than what Spurs have got.

    John Oliver urges Congress to act on Comey's firing: 'It's on you'

    Oliver started questioning the integrity of the White House due to the conflicting reasons they initially gave for the firing. John Oliver has lobbed a giant, comedic grenade at New Zealand - or, as he prefers to call it, "wallaby f-- island".
    India, Pakistan face off in ICJ over Jadhav

    India, Pakistan face off in ICJ over Jadhav

    We want appropriate legal representation for Jadhav, India told the UN's main judicial body which has stayed his death sentence. Pakistan has alleged that Jadhav was an agent of India's external intelligence agency Research and Analysis Wing (RAW).


Popular

Billiton name to disappear from BHP
Major growth projects valued at up to US$25 billion offer potential average returns of over 16 per cent at consensus prices. Elliott, run by billionaire Paul Singer, has accused BHP of adopting a "do nothing" approach to its three-pronged proposal.

Euro hits six-month peak on European unity and US divisions
The dollar index, which measures the greenback's value against a basket of six major currencies, eased 0.1 percent to 98.805. The dollar index, which tracks the US currency against a basket of six major rivals, was last at 98.118, flat on the day.

Harry Styles drops in to surprise fans at film screening
I'm lucky if everything [we went through together] helped create those songs . As it announces, it is "mainly focused on promoting Harry Styles' projects".

Assemblyman to host town hall meeting in Rome on health care proposal
Senate Majority Leader Mitch McConnell has invited all Republicans to join with the Senate group crafting the bill. You knew there were 217 yes votes to pass the bill, thus your no vote would raise your standing in your district.

Plane with New York CEO, 3 others, missing in Bahamas
At the time, the aircraft was off Eleuthera, flying at a speed of 300 knots at an altitude of 24,000 feet, the Coast Guard said. Blumin is the founder and CEO of Skylight Group , a New York-based event space company specializing in the fashion industry.

Logan gets black-and-white trailer for Noir release
What follows is a tense scene of Keen and Jackman yelling at each other (heads up for NSFW cursing) with an incredible ferocity. What landed Keen the role was not just her raw talent, but also her improvisation. "She was really a remarkable discovery".

Olympian McKayla Maroney Not Hacked After Sexy Instagram Video
Initially some fans thought her account got hacked , as they were shocked that the Olympic darling would put on such a peep show. The brunette beauty made headlines after winning her medal at the London Olympics when she pulled a face on the medal podium.

China's economy slows from recent bounce
Due to the threat posed by cheap credit-fuelled stimulus, Beijing has tightened the screws on speculative financing in the past few months.

Pippa Middleton has HUGE glass marquee installed in garden
As the future queen, Kate would risk upstaging the bride and so may wish to remain in the background for the big day next week. Famous guests, in addition to Kate and William, will reportedly be Prince Harry, Meghan Markle , Ben Fogle and Roger Federer.

Social Security Administration releases most popular baby names list
As for other names in the headlines, the data showed Donald, as in President Donald Trump, fell 45 spots past year to No. 488. The name Zayn also rose in 2016, which could be based on Zayn Malik, the former One Direction star, Forbes reported.